Product Review: Lancome’s Genifique Skin Activator

by Bionic Beauty on 24.Aug.2009 · 37 comments

Lancome’s latest anti-aging skin care product Genifique’s tagline is “Active the skin you were born with”. In traditional Bionic Beauty form, I’m here to analyze the marketing claims, ingredients, and performance of this new skin care breakthrough.

The Bionic Beauty blog reviews Lancome Genifique serum

This is what the Lancome marketing materials state-

Youth is in your genes. Reactivate it.
Discover the skin you were born to have.
Lancôme invents our first skincare that boosts the activity of genes.
At the very origin of your skin’s youth: your genes.
Genes produce specific proteins. With age, their presence diminishes.

What??? I do agree that Genifique (early Lancome marketing spelled it Genefique) worked well to reduce my signs of wrinkles, but there is no way a yeast based activator (which is the consistency of a serum) is going to reactivate or alter your genes.

Bionic’s analysis of the main ingredients:

  • Bio-Lysat (bifida ferment lysate) – This ingredient is pretty common in probiotic supplements. It’s a gram-positive bacteria that is naturally found in our digestive tract. However, there’s no scientific studies to show effects on the skin (yet). Claims are that it helps maintain the microbial status of your skin cells.
  • Hepes (hydroxyethylpiperazine ethane sulfonic acid) – This ingredient will help brighten dark patches, melasma, or other pigmentation issues. (For further reference:
  • Phystosphingosine-SLC (Salicyloyl Phytosphingosine) – “Salicyloyl Phytosphingosine is a derivative of the naturally occurring skin-identical phytosphingosine (PS) which itself has been shown to be an active ingredient with marked skin soothing properties that acts to balance the skin’s microflora in a wide variety of skincare application.” (source: Bionic Beauty says: Lancome’s Genifique Phystosphingosine-SLC formula basically combines Phytosphingosine with a Salicylic Acid derivative to help balance skin and improve texture. I’m not sure of the concentrate of Phystosphingosine-SLC in Genifique, but to be effective it needs to be over 0.05% (my bottle doesn’t have an ingredients listing).
  • Denatured alcohol – This is probably what is causing some reports of dryness and acne after using Genifique. Alcohol dries your skin, plain and simple. Be sure to moisturize after using any product with alcohol as one of the top ingredients.

Genefique is certainly functional, nothing stellar, as a wrinkle reducer. It applies nicely and sinks right into the skin. I did have to use about a dime-size amount which is a little larger than a more concentrated potion such as YBF Skincare’s line (where I use a pea-size amount daily). Remember to apply a moisturizer after about 10 minutes. You should see fine lines start to diminish in seven-ten days. And if you are like me, your skin will feel softer immediately.

Basically, since I am a big fan of research, I want my readers to know the ins and outs of what you may consider buying. Long term with Genifique, who knows? Maybe if you use it for 2 years, you’ll start reversing like Benjamin Button. But then again, you could just end up with nice smooth skin.

But ladies, please do your research before dishing out $78 for 1 ounce of product.

Genifique is available at Lancome counters or

Since I believe everyone needs a few view points, here are links to other reviews of Lancome’s Genefique activator serum:
Wrinkle Cream Doctor – Lancome Genifique Review: Does It Work?
Hey Dollface – Reports with her 7 day Lancome Genifique Checkin
Daily Cookie – Gorgeous skin when it counts with Lancome’s Genefique

Love your genes and jeans,
Don’t go changing,
Jami - author and editor of the Bionic Beauty blog


1 Briana August 25, 2009 at 4:55 pm

I tried this a couple of month’s ago. I really try to be positive, but this one didn’t impress Me.

It was sticky, and yes, took more product than usual to cover the same area. I didn’t notice any changes or improvement’s.

If it was all I had, I would use it instead of going without, but I do like the brand’s with pure, simple ingredient’s.

I think the bottle is gorgeous, but that’s where the $78 comes in!!

I do like the Lancome brand, but I suggest you at least try the store “tester” before you buy!

2 yasmin October 5, 2009 at 4:37 pm

I just began to use Genifique by Lancome. In a few weeks I’ll let you know if it works on me. Since I’m now 40 years young and my skin seems more delicate than before, I will follow your advice to use a
moisturizer 10 minutes after I apply Genifique.

I also bought Renergie Microlift—Can you advice me on how to use it.

Thanks in advance, Yasmin

3 Bionic Beauty October 9, 2009 at 9:23 pm

HI Yasmin, Thanks so much for stopping by Bionic Beauty! I can’t wait to hear your personal experience with Genifique. Please be sure you let us all know!

I’m not sure about the Renergie Microlift. I haven’t heard of it, and haven’t had the chance to buy it yet. I’ll definitely keep an eye out though. Where did you purchase it from? We might be able to get some guidance from the company itself.

Thanks again and welcome to Bionic Beauty!!
All the best,

4 Crystal October 23, 2009 at 12:08 am

Hi Yasmin,
I am a Lancome Beauty Advisor….Is your Renergie Microlift a serum or a moisturizer? If it is the serum…you would follow your cleansing routine…use your Genifique…the use the serum…remember a little goes a long way….then you would follow with your moisturizing routine. If it is the moisturizer….same thing cleanse….Genifique…then moisturize. I hope this helps

5 Nina Dana October 30, 2009 at 5:16 pm

I initially went to the store to get something to remove a few very small post acne scars on my face. The sales lady told me this is will do it. I had my reservations about this removing my post acne scars. I do have good skin and not many noticable wrinkles, so I’m thinking I may go take this back. Any suggestions??

6 Bionic Beauty November 1, 2009 at 9:02 pm

Hi Nina, I would personally suggest something from YBF Skincare ( or Lexli Skincare ( Both have exceptional products that should help with your resurfacing and skin “makeover”. 🙂

Both are 2 of my all-time favorite skin care brands. I personally use them.

I hope this helps! And thanks for being a Bionic Beauty reader! I hope to see you around the website in the future.

7 Marla January 28, 2010 at 6:02 pm

I got a free tube of this as a gift with a purchase. I like it and was considering buying it until I saw the outrageous price. I just can’t see spending that much on skin care of any kind or brand name, I don’t care how pretty the bottle is. Is there a similar product out there for us early 40-year olds who are wanting to slow down the wrinkle process? 2nd question: Isn’t a good moisturizer enough? Do we really need the various layers of products?

8 Bionic Beauty February 3, 2010 at 1:16 pm

Hi Marla, First let me welcome you to Bionic Beauty!
If you’d like a cheaper eye cream, try one of the ones from L’Oreal at the drugstore. They are owned & branded by Lancome and mostly have the same ingredients. My favorite “less expensive” eye cream is my Boots. You’ll find it at Target stores in the USA. It’s called Restore & Renew. It’s one of the few eye creams and age-reversal serums that *actually works*!

I’m also testing a few: Philosophy’s Eye Hope, Sea Pure’s eye cream (LOVE this one). But I’m not sure on the prices of those yet. I’ll have full reviews up soon.

My favorite eye cream is Correct by YBF Skincare ( Yes, it’s pricey, but the bottle will last you around 6 months if you just use it on your eyes. So the cost per use drops dramatically.

If you have healthy skin and your family gene pool is not prone to wrinkles, age spots, under eye circles, hyperpigmentation- yes, you may just be able to use a good moisturizer and cleanser. otherwise, if you have any wrinkles, you’ll probably want something dedicated to the eye area. Put that on before your face cream… then wait about 15-30 minutes, then apply your face cream/lotion over top. Face lotions/creams do not typically have the condensed anti-aging properties that eye serums/creams do. So basically, their results are watered down.

I hope this helps! Please let me know if you have any questions.
Best regards,

9 melissa April 3, 2010 at 4:38 pm

I have stumbled upon your site while looking for a review of Genifique and would love your advice on diminishing age/sun spots. I have very fair skin and after the birth of my child I have many brown spota on my face.

Any advice would be appreciated.


10 Bionic Beauty April 14, 2010 at 12:17 pm

Hi Melissa,
I’m doing some research for you on past articles I have written with products that should help you out. In the meantime, I suggest you enter the SkinBright giveaway. I’m using SkinBright currently and it’s working wonderfully on my melasma (melasma is a darkening of the skin caused sometimes by hormones, worsened by the sun, etc. It’s another version of hyperpigmentation)!! Here’s the SkinBright GIveaway on Bionic Beauty.

And welcome to Bionic Beauty! I really hope to see you around here in the future. I’ll be in touch shortly with a list of products that worked for me! 🙂 And for what it’s worth, the Genefique didn’t help with my dark spots at all. It’s more of an anti-aging, wrinkle serum. It’s not designed to brighten or exfoliate or help with the reduction of dark spots or hyperpigmentation. Stay tuned, and in the meantime, feel free to comment back, or browse the other articles here on BB.

Have a great week!
All my best,

11 Bionic Beauty April 14, 2010 at 4:30 pm

Hello again Melissa,
Here are the products that I recommend very highly to reduce melasma, dark spots, age spots, or hyperpigmentation: Lexli’s AloeGlyC, YBF Skincare’s Restore, and the StarLite laser. I know they are all a bit pricey, but I have tried every over-the-counter and drugstore lightening/brightening product, and they just don’t work. Plus they usually contain Hydroquinone which can be a very nasty ingredient.

Also, don’t forget the new SkinBright – that is also working VERY well for me!

In testing- I am using Clinique’s Dark Spot Corrector which is just hitting store shelves, and also the NuSkin at home spa system. Those are both working well for me, but I haven’t had a chance to finish up the testing yet. I typically test all skin care products for at least six weeks to verify if they are, or are not, effective.

I hope this information helps. And thanks again for being a Bionic Beauty reader!

12 Silvia Barcellos April 17, 2010 at 10:35 pm

Hello, Jami! I just got a sample size Genefique and I was researching on the web, so I found your great site! I´m from Brazil, here Genefique costs even more: US$ 150!!! Can you believe? We have lots of taxes for imported goods. We have to pay US$ 50 for a Lâncome lipstick, a domestic one with similar quality costs US$ 15. It´s insane!!! Brazilians wait to travel, so they buy everything abroad. I read your tips about products to erase acne scars, but the brands you use don´t sell here. Do you have other favorites?

13 Bionic Beauty April 20, 2010 at 11:27 am

Silvia, Oh my goodness, those prices are outrageous! I certainly agree that you need to find something that works that you will not need to import. Have you tried plain Jojoba Oil? That has excellent anti-oxidants in it, plus healing properties since it’s so close to our face’s natural sebum. It has really helped me heal up my acne scars!

Let me know and never hesitate to comment with questions.

14 Pronoy May 9, 2010 at 11:19 pm

Hello, Lancome Malesma Cream is very effective for my face malesma. Its amazing for me. Thanks Lancome.

15 Bionic Beauty May 10, 2010 at 8:47 am

Hi Pronoy, Welcome to Bionic Beauty! Which Lancome face cream are you using? They don’t have one specifically for Melasma, nor any tailored for that purpose. If you could share the name of their product that’s working to treat your melasma- I would appreciate it! And I know several other Bionic Beauties would love the help too!

Thanks! And I really hope to see you around the blog in the future.

16 vicky August 3, 2010 at 12:09 pm

Hi, I would like to know if I’m too early to start using Genifique Concentrate as my night cream as I am only 22 years old?. But my skin has improved significantly when I changed to Lancome’s products. I am currently using Primordiale range for day and night cream. Hope to hear your advice soon. Thanks!! =D

17 Bionic Beauty August 24, 2010 at 1:59 pm

Hi Vicky,
I would say there’s no age limit on using any particular skin care product. Personally, I do not see the benefit in Genefique since according to the ingredients list- it is much pricier than it should be. However, some people believe in it and have good results. Maybe see if your local Lancome counter can give you some samples to bring home before you buy a bottle (see some of the comments above).

Personally, at 22- I would concentrate more on prevention than reversal products. Jojoba Oil for moisture & antioxidants, YBF ( or Lexli skincare ( for daily serums, eye creams, exfoliation, etc. A good weekly schedule of once a week exfoliation, gentle daily washing, removing makeup with a homemade/gentle eye makeup remover (here’s my recipe:, SPF lotion EVERY day. Then tailor the rest to your particular skin- do you have sensitivity, acne, clogged pores, wrinkles starting, oily skin, combo, etc.

For the record, I’m in my mid-30s and rarely use true anti-aging skincare except when testing. My skin is combo oil/normal, prone to extreme sensitivity to certain ingredients, and have some breakouts/clogged pores which I treat with Tea Tree Oil, Lexli & YBF products, a natural Sulfur Cream, and Jojoba Oil.

I hope this helps!
Best regards,

18 kelly November 10, 2010 at 7:48 pm

hi yami, i’m 30, and starting to get conscious of fine lines – especially around my eyes! Could you recommend a good eyecream that is ok for my age group? Also, should i be using an ‘anti wrinkle’ moisturiser?

19 Tee November 14, 2010 at 3:15 pm

Hi all, do not buy the Lancome Genifique!! It has really screwed up my skin, I am in my late forties and I have NEVER had a problem with break-outs, I now am getting acne!! I think it messes with something at cellular level.. who knows the long term damage that this “science” can do to us. I am just sick that I ever bought into such B.S. Thanks

20 Bionic Beauty November 18, 2010 at 12:12 pm

Hi Tee, I’m sorry Genefique did not work for you. I did not have luck with it either. However, just remember that NO cream or lotion can change your skin on a DNA, gene or cellular level. Those are all just marketing ploys and they are running rampant these days. So be careful and do loads of research before purchasing. Even ingredients lists can be incomplete or misleading these days. It’s sad… but hopefully blogs and honest forums can help us all chose better products that actually disclose ingredients AND benefit your skin. 🙂 Makeup is just as hard- especially when you are allergic to so many ingredients as I am. I finally found a good-for-my-skin makeup that is affordable and looks gorgeous on! But it took me trying over 50 brands!

I hope to see you around Bionic Beauty in the future!

21 EM November 20, 2010 at 7:03 pm

Hi, I’m just wondering whether you have tried the Genifique night cream.
I tried the serum and really really love it. But I thought if I buy the cream, then I don’t have to buy a separate night moisturizer.
Do you think the cream will be as good as the serum? and what day cream from lancome that you recommend for sensitive skin?
Also, do you think we can apply this around our eyes?


22 Bionic Beauty November 21, 2010 at 1:42 pm

Hi EM, Welcome to Bionic Beauty! Thanks for stopping by and asking your questions about Lancome’s Genefique line. Unfortunately, like my review above- I can’t whole-heartedly stand behind this line. Some of the claims made are beyond possibility in Physics and the cost is just exorbitant. Personally, I would spend my money on something that has more care and research in the ingredients, more concentrated and less marketing fluff.

Then again, you are having great luck with the serum, so this might be a match for you. If you are considering trying the day cream- I would recommend going to your local Lancome counter first and asking for samples. They usually have plenty. That way you can test it for at least a week and check for any adverse reactions. Granted- ANY skin care item will take at least 4-6 weeks to show any improvement or true reactions so be careful.

Feel free to post back with any more questions!

23 miles November 23, 2010 at 8:58 pm

Hi, miles here, I was wondering if there is a way to get a sample of this stuff to try it. I have always thought the body could heal itself, and this isjust what I am talking about. Thanks miles

24 Bionic Beauty December 4, 2010 at 7:02 pm

Hi Miles, Thanks for posting here on Bionic Beauty – welcome to the beauty blog! Unfortunately, I do not provide any samples, or sell any products- Bionic Beauty is basically a beauty magazine that is only published online, updated daily and for FREE! 🙂 If you’d like a sample of Lancome’s Genefique to try, I would suggest heading to your local Lancome department store counter and asking one of the consultants for a sample to last you a few weeks. That way you can save money if it doesn’t work for you (since it’s getting VERY mixed reviews and will NOT change your genes no matter what they say in their marketing campaigns).

I hope to see you around Bionic Beauty in the future.

25 Joanne Griffin December 30, 2010 at 9:06 am

I got a sample of Genefique from Sephora so I am just now trying it. It’s hard to pay that much for a product but I always say, if it works, I will do it. I am in my forties and starting to see fine lines and some sagging in my eye area. What do you suggest for this problem. I’m also getting dry where normally I am oily to normal. It might be because of the cold air, not sure. I’m afraid this is contributing to my fine lines.

26 mary January 2, 2011 at 9:39 pm

Dear Melissa,

I was reading your comments on Genifique. I went to the store asking for something to help with serious dicoloration on my face due to hormone treatment. And also something to help give a youthful glow. I was given genifique night repair cream and the youth activating serum.I have used them for a few days and noticed some burning sensation around my eye lids/under eye areas. I also noticed my face getting darker. So I decided to stop usage and do some research. That was how I came to your page. Please could you advice me on what to do?

27 jan March 15, 2011 at 7:00 pm

jst found your site by accident. its gr8. i suffer from poly cystic ovaries, so every now and then i have mild acne which have left scars so i m constantly using foundation to cover them up.
whats a good product that i can use to get my skin back to normal and rid of the scars?

28 Michelle O May 26, 2011 at 7:30 pm

Thought about buying genefique by lancome but since i still have a full jar of the Olive Night Creme from Made from Earth, i gave it one last try. So i’ve been using this nightly for a month now and texture of my cheeks are firmer since using it. The laugh lines around my nose and mouth are diminishing. glad i did not turn to using the $100 products because this stuff works as well 🙂

29 antoinette priore June 24, 2011 at 3:49 pm

hi wondering what ybf stands for and where can i purchase them or find out about them. Stumbled across your web site asking about genifique. Thank you for any help you can offer. I often get taken with make up products especially skin products, any help would help.

Thank you. Antoinette

30 Megan September 30, 2011 at 10:52 pm

As a Lancome employee, I feel you are misinformed about Genifique. Genifique helps bring radiance to skin (radiance is shown to decrease as skin ages) and to give skin a very soft, smooth texture. In my experience Genifique does this outstandingly. This is how Genifique helps the skin appear younger. However, Genifique does not affect the appearance of wrinkles or help lighten dark spots. In my experience, the results with Genifique are outstanding. I do especially love the Genifique Repair Night Cream.

31 Dasha December 26, 2011 at 8:12 am

How and when to use Genifique?

32 bequeen April 28, 2012 at 11:20 am

Ever since using Genifique,it’s truly amazing result. My skin glowing,smoothier and brighter in less than 2 months. I get terrific response and feedback from people around me esp first when my sister asked why my skin looked so glowing and smooth and thought I used foundation or concealer. Some started to noticed and asking why is my skin become brighter and smoother and I wonder which Lancome skincare range gave this result until I found I stopped using Genifique for a week and continue using again. Know that it’s quite pricy but worth the price.

orth for long term investment cos it’s really give you amazing youth skin. I’m in my 30’s but it makes me feel youth.

33 Barbara July 23, 2012 at 6:54 pm

Hi Jami,
So greatful running across your site ! Didn’t know about it until this moment when I went on line to find out the ingredients in Genifique serum, and found your great input.. Have used the expensive product (Genifique) in the past, and did notice a little smoother appearance to my skin, which is normal / oily in the T-Zone area. I am in my mid 60’s, and have wonderful skin with some wrinkling only by my eyes, and only noticeable when smiling. Have tried many products, but really have not found one great one I could count on. Think the smooth complexion is genetic, and would like to keep it that way. Could you recommend the best anti-wrinkle, anti-aging serum, as well as a moisturizer for somewhat oily skin ? I breakout easily if the moisturizer has too much mineral oil, or whatever kind of oil they may use. Was going to purchase Genifique, but after reading your reviews, I’ll save my money, and purchase the products you recommend ! that actually work ! Thank you….

34 Tiffany March 5, 2013 at 5:51 pm

I tried the 7 day sample…after about 3 days I noticed my face was really red and anything I put on…even face would burn so bad!! I washed my face before, then applied Genifique followed by mositurizing. ITS HORRIBLE!! The burning sensation is still there and my face is puffy. I read other reviews and alot of other people having the same issue.

35 Connie July 6, 2013 at 10:09 am

I need advise on what products to use on my skin for getting rid of whitheads.
I am 55 years old, not much sun damage but dry skin. The whiteheads started appearing during menopause. I have been over that for a few years but the whiteheads are still with me. I have tried microdermabrasion and several other skin treatments but can not get rid of these unsightly bumps. Advise,

36 April Stewart January 10, 2017 at 12:26 pm

I have been using this for approx. 3 months. I loved the glow I got at first. Now my skin is dry, peeling and is having acne. I usually never have acne. My skin looks dull and feels un even. I do moisture afterwards. Any suggestions ?

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