Lancome’s latest anti-aging skin care product Genifique’s tagline is “Active the skin you were born with”. In traditional Bionic Beauty form, I’m here to analyze the marketing claims, ingredients, and performance of this new skin care breakthrough.
Bionic Beauty analyzes Lancome's Genifique
This is what the Lancome marketing materials state-
Youth is in your genes. Reactivate it.
Discover the skin you were born to have.
Lancôme invents our first skincare that boosts the activity of genes.
At the very origin of your skin’s youth: your genes.
Genes produce specific proteins. With age, their presence diminishes.
What??? I do agree that Genifique (early Lancome marketing spelled it Genefique) worked well to reduce my signs of wrinkles, but there is no way a yeast based activator (which is the consistency of a serum) is going to reactivate or alter your genes.
Bionic’s analysis of the main ingredients:
- Bio-Lysat (bifida ferment lysate) – This ingredient is pretty common in probiotic supplements. It’s a gram-positive bacteria that is naturally found in our digestive tract. However, there’s no scientific studies to show effects on the skin (yet). Claims are that it helps maintain the microbial status of your skin cells.
- Hepes (hydroxyethylpiperazine ethane sulfonic acid) - This ingredient will help brighten dark patches, melasma, or other pigmentation issues. (For further reference: http://www.faqs.org/patents/app/20090192124)
- Phystosphingosine-SLC (Salicyloyl Phytosphingosine) - “Salicyloyl Phytosphingosine is a derivative of the naturally occurring skin-identical phytosphingosine (PS) which itself has been shown to be an active ingredient with marked skin soothing properties that acts to balance the skin’s microflora in a wide variety of skincare application.” (source: Cosmolara.com). Bionic Beauty says: Lancome’s Genifique Phystosphingosine-SLC formula basically combines Phytosphingosine with a Salicylic Acid derivative to help balance skin and improve texture. I’m not sure of the concentrate of Phystosphingosine-SLC in Genifique, but to be effective it needs to be over 0.05% (my bottle doesn’t have an ingredients listing).
- Denatured alcohol - This is probably what is causing some reports of dryness and acne after using Genifique. Alcohol dries your skin, plain and simple. Be sure to moisturize after using any product with alcohol as one of the top ingredients.
Genefique is certainly functional, nothing stellar, as a wrinkle reducer. It applies nicely and sinks right into the skin. I did have to use about a dime-size amount which is a little larger than a more concentrated potion such as YBF Skincare’s line (where I use a pea-size amount daily). Remember to apply a moisturizer after about 10 minutes. You should see fine lines start to diminish in seven-ten days. And if you are like me, your skin will feel softer immediately.
Basically, since I am a big fan of research, I want my readers to know the ins and outs of what you may consider buying. Long term with Genifique, who knows? Maybe if you use it for 2 years, you’ll start reversing like Benjamin Button. But then again, you could just end up with nice smooth skin.
But ladies, please do your research before dishing out $78 for 1 ounce of product.
Genifique is available at Lancome counters or Lancome-USA.com.
Since I believe everyone needs a few view points, here are links to other reviews of Lancome’s Genefique activator serum:
Wrinkle Cream Doctor – Lancome Genifique Review: Does It Work?
Hey Dollface – Reports with her 7 day Lancome Genifique Checkin
Daily Cookie – Gorgeous skin when it counts with Lancome’s Genefique

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{ 17 comments… read them below or add one }
I tried this a couple of month’s ago. I really try to be positive, but this one didn’t impress Me.
It was sticky, and yes, took more product than usual to cover the same area. I didn’t notice any changes or improvement’s.
If it was all I had, I would use it instead of going without, but I do like the brand’s with pure, simple ingredient’s.
I think the bottle is gorgeous, but that’s where the $78 comes in!!
I do like the Lancome brand, but I suggest you at least try the store “tester” before you buy!
Briana
I just began to use Genifique by Lancome. In a few weeks I’ll let you know if it works on me. Since I’m now 40 years young and my skin seems more delicate than before, I will follow your advice to use a
moisturizer 10 minutes after I apply Genifique.
QUESTION:
I also bought Renergie Microlift—Can you advice me on how to use it.
Thanks in advance, Yasmin
HI Yasmin, Thanks so much for stopping by Bionic Beauty! I can’t wait to hear your personal experience with Genifique. Please be sure you let us all know!
I’m not sure about the Renergie Microlift. I haven’t heard of it, and haven’t had the chance to buy it yet. I’ll definitely keep an eye out though. Where did you purchase it from? We might be able to get some guidance from the company itself.
Thanks again and welcome to Bionic Beauty!!
All the best,
Jami
Hi Yasmin,
I am a Lancome Beauty Advisor….Is your Renergie Microlift a serum or a moisturizer? If it is the serum…you would follow your cleansing routine…use your Genifique…the use the serum…remember a little goes a long way….then you would follow with your moisturizing routine. If it is the moisturizer….same thing cleanse….Genifique…then moisturize. I hope this helps
I initially went to the store to get something to remove a few very small post acne scars on my face. The sales lady told me this is will do it. I had my reservations about this removing my post acne scars. I do have good skin and not many noticable wrinkles, so I’m thinking I may go take this back. Any suggestions??
Hi Nina, I would personally suggest something from YBF Skincare (www.ybf-skincare.com) or Lexli Skincare (www.lexli.com). Both have exceptional products that should help with your resurfacing and skin “makeover”.
Both are 2 of my all-time favorite skin care brands. I personally use them.
I hope this helps! And thanks for being a Bionic Beauty reader! I hope to see you around the website in the future.
Cheers,
~Jami
I got a free tube of this as a gift with a purchase. I like it and was considering buying it until I saw the outrageous price. I just can’t see spending that much on skin care of any kind or brand name, I don’t care how pretty the bottle is. Is there a similar product out there for us early 40-year olds who are wanting to slow down the wrinkle process? 2nd question: Isn’t a good moisturizer enough? Do we really need the various layers of products?
Hi Marla, First let me welcome you to Bionic Beauty!
If you’d like a cheaper eye cream, try one of the ones from L’Oreal at the drugstore. They are owned & branded by Lancome and mostly have the same ingredients. My favorite “less expensive” eye cream is my Boots. You’ll find it at Target stores in the USA. It’s called Restore & Renew. It’s one of the few eye creams and age-reversal serums that *actually works*!
I’m also testing a few: Philosophy’s Eye Hope, Sea Pure’s eye cream (LOVE this one). But I’m not sure on the prices of those yet. I’ll have full reviews up soon.
My favorite eye cream is Correct by YBF Skincare (www.ybf-skincare.com). Yes, it’s pricey, but the bottle will last you around 6 months if you just use it on your eyes. So the cost per use drops dramatically.
If you have healthy skin and your family gene pool is not prone to wrinkles, age spots, under eye circles, hyperpigmentation- yes, you may just be able to use a good moisturizer and cleanser. otherwise, if you have any wrinkles, you’ll probably want something dedicated to the eye area. Put that on before your face cream… then wait about 15-30 minutes, then apply your face cream/lotion over top. Face lotions/creams do not typically have the condensed anti-aging properties that eye serums/creams do. So basically, their results are watered down.
I hope this helps! Please let me know if you have any questions.
Best regards,
Jami
I have stumbled upon your site while looking for a review of Genifique and would love your advice on diminishing age/sun spots. I have very fair skin and after the birth of my child I have many brown spota on my face.
Any advice would be appreciated.
Thanks!
Hi Melissa,
I’m doing some research for you on past articles I have written with products that should help you out. In the meantime, I suggest you enter the SkinBright giveaway. I’m using SkinBright currently and it’s working wonderfully on my melasma (melasma is a darkening of the skin caused sometimes by hormones, worsened by the sun, etc. It’s another version of hyperpigmentation)!! Here’s the SkinBright GIveaway on Bionic Beauty.
And welcome to Bionic Beauty! I really hope to see you around here in the future. I’ll be in touch shortly with a list of products that worked for me!
And for what it’s worth, the Genefique didn’t help with my dark spots at all. It’s more of an anti-aging, wrinkle serum. It’s not designed to brighten or exfoliate or help with the reduction of dark spots or hyperpigmentation. Stay tuned, and in the meantime, feel free to comment back, or browse the other articles here on BB.
Have a great week!
All my best,
Jami
Hello again Melissa,
Here are the products that I recommend very highly to reduce melasma, dark spots, age spots, or hyperpigmentation: Lexli’s AloeGlyC, YBF Skincare’s Restore, and the StarLite laser. I know they are all a bit pricey, but I have tried every over-the-counter and drugstore lightening/brightening product, and they just don’t work. Plus they usually contain Hydroquinone which can be a very nasty ingredient.
Also, don’t forget the new SkinBright – that is also working VERY well for me!
In testing- I am using Clinique’s Dark Spot Corrector which is just hitting store shelves, and also the NuSkin at home spa system. Those are both working well for me, but I haven’t had a chance to finish up the testing yet. I typically test all skin care products for at least six weeks to verify if they are, or are not, effective.
I hope this information helps. And thanks again for being a Bionic Beauty reader!
Jami
Hello, Jami! I just got a sample size Genefique and I was researching on the web, so I found your great site! I´m from Brazil, here Genefique costs even more: US$ 150!!! Can you believe? We have lots of taxes for imported goods. We have to pay US$ 50 for a Lâncome lipstick, a domestic one with similar quality costs US$ 15. It´s insane!!! Brazilians wait to travel, so they buy everything abroad. I read your tips about products to erase acne scars, but the brands you use don´t sell here. Do you have other favorites?
Silvia, Oh my goodness, those prices are outrageous! I certainly agree that you need to find something that works that you will not need to import. Have you tried plain Jojoba Oil? That has excellent anti-oxidants in it, plus healing properties since it’s so close to our face’s natural sebum. It has really helped me heal up my acne scars!
Let me know and never hesitate to comment with questions.
Cheers,
Jami
Hello, Lancome Malesma Cream is very effective for my face malesma. Its amazing for me. Thanks Lancome.
Hi Pronoy, Welcome to Bionic Beauty! Which Lancome face cream are you using? They don’t have one specifically for Melasma, nor any tailored for that purpose. If you could share the name of their product that’s working to treat your melasma- I would appreciate it! And I know several other Bionic Beauties would love the help too!
Thanks! And I really hope to see you around the blog in the future.
Cheers,
Jami
Hi, I would like to know if I’m too early to start using Genifique Concentrate as my night cream as I am only 22 years old?. But my skin has improved significantly when I changed to Lancome’s products. I am currently using Primordiale range for day and night cream. Hope to hear your advice soon. Thanks!! =D
Hi Vicky,
I would say there’s no age limit on using any particular skin care product. Personally, I do not see the benefit in Genefique since according to the ingredients list- it is much pricier than it should be. However, some people believe in it and have good results. Maybe see if your local Lancome counter can give you some samples to bring home before you buy a bottle (see some of the comments above).
Personally, at 22- I would concentrate more on prevention than reversal products. Jojoba Oil for moisture & antioxidants, YBF (http://bionic-beauty.com/category/brands/ybf-skincare/) or Lexli skincare (http://bionic-beauty.com/category/brands/lexli/) for daily serums, eye creams, exfoliation, etc. A good weekly schedule of once a week exfoliation, gentle daily washing, removing makeup with a homemade/gentle eye makeup remover (here’s my recipe: http://bionic-beauty.com/make-makeup-remover/), SPF lotion EVERY day. Then tailor the rest to your particular skin- do you have sensitivity, acne, clogged pores, wrinkles starting, oily skin, combo, etc.
For the record, I’m in my mid-30s and rarely use true anti-aging skincare except when testing. My skin is combo oil/normal, prone to extreme sensitivity to certain ingredients, and have some breakouts/clogged pores which I treat with Tea Tree Oil, Lexli & YBF products, a natural Sulfur Cream, and Jojoba Oil.
I hope this helps!
Best regards,
Jami